High glucose reduces Nrf2-dependent cRAGE release and enhances inflammasome-dependent IL-1β production in monocytes: the modulatory effects of EGCG

High glucose reduces Nrf2-dependent cRAGE release and enhances inflammasome-dependent IL-1β production in monocytes: the modulatory effects of EGCG

Soluble receptor for advanced glycation end products (sRAGE) acts as a decoy sequestering of RAGE ligands, thus preventing the activation of the ligand-RAGE axis linking human diseases. However, the molecular mechanisms underlying sRAGE remain unclear. In this study, THP-1 monocytes were cultured in...

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Bibliographic Details
Main Authors: Chi-Hao Wu, Yin-Hsuan Chang, Chin-Lin Hsu, Sheng-Yi Chen, Gow-Chin Yen
Format: Article
Language:English
Published: Tsinghua University Press 2024-05-01
Series:Food Science and Human Wellness
Subjects:
epigallocatechin gallate (egcg)
inflammasome
nuclear factor erythroid 2-related factor 2 (nrf2)
receptor for advanced glycation end products (rage)
soluble rage (srage)
Online Access:https://www.sciopen.com/article/10.26599/FSHW.2022.9250129
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https://www.sciopen.com/article/10.26599/FSHW.2022.9250129

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