Identification of determinants that allow maintenance of high-level fluoroquinolone resistance in Acinetobacter baumannii

ABSTRACT Acinetobacter baumannii is associated with multidrug-resistant infections in healthcare settings, with fluoroquinolones such as ciprofloxacin being currently ineffective. Clinical isolates largely harbor mutations in the GyrA and TopoIV fluoroquinolone targets, as well as mutations that inc...

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Bibliographic Details
Main Authors: Efrat Hamami, Wenwen Huo, Juan Hernandez-Bird, Arnold Castaneda, Jinna Bai, Sapna Syal, Juan C. Ortiz-Marquez, Tim van Opijnen, Edward Geisinger, Ralph R. Isberg
Format: Article
Language:English
Published: American Society for Microbiology 2025-01-01
Series:mBio
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Online Access:https://journals.asm.org/doi/10.1128/mbio.03221-24
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