Revealing the role of increased SK3 expression in sulfonylurea resistance triggered by prolonged exposure
Abstract Background Sulfonylureas have long been utilized in the management of type-2 diabetes mellitus (T2DM) due to their insulin-secretagogue properties. However, their clinical efficacy is hindered by the risk of severe hypoglycemia and secondary sulfonylurea failure. While the mechanisms underl...
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| Main Authors: | Jung Gyu Park, Minseok Kim, Sungje Yoo, Sun Wook Hwang, Jongsoo Mok, Joonghoon Park, Keon Wook Kang |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-06-01
|
| Series: | Nutrition & Diabetes |
| Online Access: | https://doi.org/10.1038/s41387-025-00384-9 |
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