Revealing the role of increased SK3 expression in sulfonylurea resistance triggered by prolonged exposure

Abstract Background Sulfonylureas have long been utilized in the management of type-2 diabetes mellitus (T2DM) due to their insulin-secretagogue properties. However, their clinical efficacy is hindered by the risk of severe hypoglycemia and secondary sulfonylurea failure. While the mechanisms underl...

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Bibliographic Details
Main Authors: Jung Gyu Park, Minseok Kim, Sungje Yoo, Sun Wook Hwang, Jongsoo Mok, Joonghoon Park, Keon Wook Kang
Format: Article
Language:English
Published: Nature Publishing Group 2025-06-01
Series:Nutrition & Diabetes
Online Access:https://doi.org/10.1038/s41387-025-00384-9
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