Revisiting substance P in migraine: a methodological approach inspired by anti-CGRP and anti-PACAP success
Abstract Substance P, previously dismissed as a therapeutic target for migraine due to the failure of neurokinin-1 receptor antagonists, warrants renewed attention. Building on the success of therapies targeting the calcitonin gene-related peptide (CGRP) system and pituitary adenylate cyclase-activa...
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Main Authors: | Lanfranco Pellesi, Lars Edvinsson |
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Format: | Article |
Language: | English |
Published: |
BMC
2025-01-01
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Series: | The Journal of Headache and Pain |
Subjects: | |
Online Access: | https://doi.org/10.1186/s10194-025-01959-8 |
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