Revisiting substance P in migraine: a methodological approach inspired by anti-CGRP and anti-PACAP success

Abstract Substance P, previously dismissed as a therapeutic target for migraine due to the failure of neurokinin-1 receptor antagonists, warrants renewed attention. Building on the success of therapies targeting the calcitonin gene-related peptide (CGRP) system and pituitary adenylate cyclase-activa...

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Bibliographic Details
Main Authors: Lanfranco Pellesi, Lars Edvinsson
Format: Article
Language:English
Published: BMC 2025-01-01
Series:The Journal of Headache and Pain
Subjects:
Online Access:https://doi.org/10.1186/s10194-025-01959-8
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