NEDD4 family E3 ligases in osteoporosis: mechanisms and emerging potential therapeutic targets
Abstract Osteoporosis is a systemic skeletal disorder characterized by reduced bone density and an increased risk of fractures, particularly prevalent in the aging population. Osteoporotic complications, including vertebral compression fractures, hip fractures, and distal forearm fractures, affect o...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Orthopaedic Surgery and Research |
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| Online Access: | https://doi.org/10.1186/s13018-025-05517-5 |
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| author | Heng Wu Junhui Zuo Yu Dai Hairui Li Song Wang |
| author_facet | Heng Wu Junhui Zuo Yu Dai Hairui Li Song Wang |
| author_sort | Heng Wu |
| collection | DOAJ |
| description | Abstract Osteoporosis is a systemic skeletal disorder characterized by reduced bone density and an increased risk of fractures, particularly prevalent in the aging population. Osteoporotic complications, including vertebral compression fractures, hip fractures, and distal forearm fractures, affect over 8.9 million individuals globally, placing a significant economic strain on healthcare systems. Recent advances have expanded our understanding of the mechanisms underlying osteoporosis, particularly the intricate regulatory networks involved in bone metabolism. A central player in these processes is ubiquitin-mediated proteasomal degradation, a crucial post-translational modification system that involves ubiquitin, the ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2), ubiquitin ligase (E3), deubiquitinating enzymes, and the proteasome. Among the various E3 ligases, the NEDD4 family has emerged as a key regulator of both bone development and osteoporotic pathology. This review delineates the role of NEDD4 family in osteoporosis and identifies potential drug targets within these pathways, offering insights into novel therapeutic approaches for osteoporosis through targeted intervention. |
| format | Article |
| id | doaj-art-bffba2689c854f51b83a8d0820e01574 |
| institution | Kabale University |
| issn | 1749-799X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj-art-bffba2689c854f51b83a8d0820e015742025-01-26T12:43:19ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2025-01-0120111210.1186/s13018-025-05517-5NEDD4 family E3 ligases in osteoporosis: mechanisms and emerging potential therapeutic targetsHeng Wu0Junhui Zuo1Yu Dai2Hairui Li3Song Wang4Department of Orthopedics, the Affiliated Hospital of Southwest Medical UniversityDepartment of Orthopedics, the Affiliated Hospital of Southwest Medical UniversityDepartment of Oncology, the Affiliated Hospital of Southwest Medical UniversityDepartment of Urology, West China Hospital of Sichuan UniversityDepartment of Orthopedics, the Affiliated Hospital of Southwest Medical UniversityAbstract Osteoporosis is a systemic skeletal disorder characterized by reduced bone density and an increased risk of fractures, particularly prevalent in the aging population. Osteoporotic complications, including vertebral compression fractures, hip fractures, and distal forearm fractures, affect over 8.9 million individuals globally, placing a significant economic strain on healthcare systems. Recent advances have expanded our understanding of the mechanisms underlying osteoporosis, particularly the intricate regulatory networks involved in bone metabolism. A central player in these processes is ubiquitin-mediated proteasomal degradation, a crucial post-translational modification system that involves ubiquitin, the ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2), ubiquitin ligase (E3), deubiquitinating enzymes, and the proteasome. Among the various E3 ligases, the NEDD4 family has emerged as a key regulator of both bone development and osteoporotic pathology. This review delineates the role of NEDD4 family in osteoporosis and identifies potential drug targets within these pathways, offering insights into novel therapeutic approaches for osteoporosis through targeted intervention.https://doi.org/10.1186/s13018-025-05517-5OsteoporosisUbiquitinationE3 ubiquitin ligaseNEDD4 ubiquitin ligase familyTherapeutics |
| spellingShingle | Heng Wu Junhui Zuo Yu Dai Hairui Li Song Wang NEDD4 family E3 ligases in osteoporosis: mechanisms and emerging potential therapeutic targets Journal of Orthopaedic Surgery and Research Osteoporosis Ubiquitination E3 ubiquitin ligase NEDD4 ubiquitin ligase family Therapeutics |
| title | NEDD4 family E3 ligases in osteoporosis: mechanisms and emerging potential therapeutic targets |
| title_full | NEDD4 family E3 ligases in osteoporosis: mechanisms and emerging potential therapeutic targets |
| title_fullStr | NEDD4 family E3 ligases in osteoporosis: mechanisms and emerging potential therapeutic targets |
| title_full_unstemmed | NEDD4 family E3 ligases in osteoporosis: mechanisms and emerging potential therapeutic targets |
| title_short | NEDD4 family E3 ligases in osteoporosis: mechanisms and emerging potential therapeutic targets |
| title_sort | nedd4 family e3 ligases in osteoporosis mechanisms and emerging potential therapeutic targets |
| topic | Osteoporosis Ubiquitination E3 ubiquitin ligase NEDD4 ubiquitin ligase family Therapeutics |
| url | https://doi.org/10.1186/s13018-025-05517-5 |
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