P-glycoprotein expression skews mitochondrial dye measurements in T cells
Assays to monitor metabolic parameters of immune cells at a single cell level provide efficient means to study immunometabolism. We show here that staining intensity of mitochondria targeting probes in T cells is dramatically influenced by P-glycoprotein/P-gp expression, a xenobiotic efflux pump tha...
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| Main Authors: | Sophia P. M. Sok, Jianan Cheng, Klaudia Strucinska, Narcis I. Popescu, Lihua Wu, Qiuqing Ke, William B. Kiosses, David Stanford, Willard M. Freeman, Satoshi Matsuzaki, Tommy L. Lewis, Meng Zhao |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1560104/full |
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