P-glycoprotein expression skews mitochondrial dye measurements in T cells

P-glycoprotein expression skews mitochondrial dye measurements in T cells

Assays to monitor metabolic parameters of immune cells at a single cell level provide efficient means to study immunometabolism. We show here that staining intensity of mitochondria targeting probes in T cells is dramatically influenced by P-glycoprotein/P-gp expression, a xenobiotic efflux pump tha...

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Bibliographic Details
Main Authors: Sophia P. M. Sok, Jianan Cheng, Klaudia Strucinska, Narcis I. Popescu, Lihua Wu, Qiuqing Ke, William B. Kiosses, David Stanford, Willard M. Freeman, Satoshi Matsuzaki, Tommy L. Lewis, Meng Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
T cells
mitochondria
oxidative phosphorilation
mitotracker
TMRE
P-glycolprotein
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1560104/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1560104/full

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