Single-cell transcriptomics reveals novel chondrocyte and osteoblast subtypes and their role in knee osteoarthritis pathogenesis
Abstract Research on treating knee osteoarthritis (KOA) is becoming more challenging due to a growing number of younger patients being affected. The pathogenesis of KOA is complex for being a multifactorial disease affecting the entire joint, with remodeling of subchondral bone playing a key role in...
Saved in:
Main Authors: | Yuan Liu, Wacili Da, Ming-Jie Xu, Chao-Xin Xiao, Tao Deng, Sheng-Liang Zhou, Xiao-Ting Chen, Yao-Jia Zhou, Li Tang, Yong Nie, Yi Zeng, Hui-Qi Xie, Bin Shen |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2025-02-01
|
Series: | Signal Transduction and Targeted Therapy |
Online Access: | https://doi.org/10.1038/s41392-025-02136-8 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Bergapten alleviates senescence of chondrocytes in osteoarthritis
by: YE Yuanlan, et al.
Published: (2025-02-01) -
Autologous Bone Marrow-Derived Chondrocytes for Patients with Knee Osteoarthritis: A Randomized Controlled Trial
by: Mir Sadat-Ali, et al.
Published: (2021-01-01) -
Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of Osteoarthritis
by: Da-Long Dong, et al.
Published: (2025-01-01) -
Skatole Alleviates Osteoarthritis by Reprogramming Macrophage Polarization and Protecting Chondrocytes
by: Weiyun Wang, et al.
Published: (2025-01-01) -
Single cell transcriptome profiling reveals pathogenesis of bullous pemphigoid
by: Guirong Liang, et al.
Published: (2025-02-01)