Single-cell transcriptomics reveals novel chondrocyte and osteoblast subtypes and their role in knee osteoarthritis pathogenesis

Single-cell transcriptomics reveals novel chondrocyte and osteoblast subtypes and their role in knee osteoarthritis pathogenesis

Abstract Research on treating knee osteoarthritis (KOA) is becoming more challenging due to a growing number of younger patients being affected. The pathogenesis of KOA is complex for being a multifactorial disease affecting the entire joint, with remodeling of subchondral bone playing a key role in...

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Main Authors: Yuan Liu, Wacili Da, Ming-Jie Xu, Chao-Xin Xiao, Tao Deng, Sheng-Liang Zhou, Xiao-Ting Chen, Yao-Jia Zhou, Li Tang, Yong Nie, Yi Zeng, Hui-Qi Xie, Bin Shen
Format: Article
Language:English
Published: Nature Publishing Group 2025-02-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02136-8
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https://doi.org/10.1038/s41392-025-02136-8

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