Fibroblast Growth Factor-2 and the HIV-1 Tat Protein Synergize in Promoting Bcl-2 Expression and Preventing Endothelial Cell Apoptosis: Implications for the Pathogenesis of AIDS-Associated Kaposi's Sarcoma
Kaposi's sarcoma (KS) is a vascular tumor frequently occurring in Human Immunodeficiency Virus- (HIV-) 1-infected individuals. Our previous work indicated that the angiogenic fibroblast growth factor (FGF)-2 and the Tat protein of HIV-1, both expressed in KS lesions of HIV-infected patients, sy...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/452729 |
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| author | Cecilia Sgadari Giovanni Barillari Clelia Palladino Stefania Bellino Brunella Taddeo Elena Toschi Barbara Ensoli |
| author_facet | Cecilia Sgadari Giovanni Barillari Clelia Palladino Stefania Bellino Brunella Taddeo Elena Toschi Barbara Ensoli |
| author_sort | Cecilia Sgadari |
| collection | DOAJ |
| description | Kaposi's sarcoma (KS) is a vascular tumor frequently occurring in Human Immunodeficiency Virus- (HIV-) 1-infected individuals.
Our previous work indicated that the angiogenic fibroblast growth factor (FGF)-2 and the Tat protein of HIV-1, both expressed in KS lesions of HIV-infected patients, synergize at inducing angioproliferative, KS-like lesions in mice.
Here we show that the development of angioproliferative lesions promoted in mice by combined Tat and FGF-2 associates with an increase in the levels of expression of the antiapoptotic Bcl-2 protein. Upregulation of Bcl-2 expression by combined FGF-2 and Tat occurs also in vitro, and this protects human primary endothelial cells from programmed cell death.
As Bcl-2 is expressed in human KS lesions in a fashion paralleling the progression of the disease, these findings suggest a molecular mechanism by which Tat and FGF-2 cooperate in KS maintenance and progression in HIV-infected individuals. |
| format | Article |
| id | doaj-art-8b33b0fbab634b5cb2e90db38b2ff327 |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-8b33b0fbab634b5cb2e90db38b2ff3272025-02-03T05:52:47ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322011-01-01201110.1155/2011/452729452729Fibroblast Growth Factor-2 and the HIV-1 Tat Protein Synergize in Promoting Bcl-2 Expression and Preventing Endothelial Cell Apoptosis: Implications for the Pathogenesis of AIDS-Associated Kaposi's SarcomaCecilia Sgadari0Giovanni Barillari1Clelia Palladino2Stefania Bellino3Brunella Taddeo4Elena Toschi5Barbara Ensoli6National AIDS Center, Istituto Superiore di Sanità, 00161 Rome, ItalyNational AIDS Center, Istituto Superiore di Sanità, 00161 Rome, ItalyNational AIDS Center, Istituto Superiore di Sanità, 00161 Rome, ItalyNational AIDS Center, Istituto Superiore di Sanità, 00161 Rome, ItalyNational AIDS Center, Istituto Superiore di Sanità, 00161 Rome, ItalyNational AIDS Center, Istituto Superiore di Sanità, 00161 Rome, ItalyNational AIDS Center, Istituto Superiore di Sanità, 00161 Rome, ItalyKaposi's sarcoma (KS) is a vascular tumor frequently occurring in Human Immunodeficiency Virus- (HIV-) 1-infected individuals. Our previous work indicated that the angiogenic fibroblast growth factor (FGF)-2 and the Tat protein of HIV-1, both expressed in KS lesions of HIV-infected patients, synergize at inducing angioproliferative, KS-like lesions in mice. Here we show that the development of angioproliferative lesions promoted in mice by combined Tat and FGF-2 associates with an increase in the levels of expression of the antiapoptotic Bcl-2 protein. Upregulation of Bcl-2 expression by combined FGF-2 and Tat occurs also in vitro, and this protects human primary endothelial cells from programmed cell death. As Bcl-2 is expressed in human KS lesions in a fashion paralleling the progression of the disease, these findings suggest a molecular mechanism by which Tat and FGF-2 cooperate in KS maintenance and progression in HIV-infected individuals.http://dx.doi.org/10.1155/2011/452729 |
| spellingShingle | Cecilia Sgadari Giovanni Barillari Clelia Palladino Stefania Bellino Brunella Taddeo Elena Toschi Barbara Ensoli Fibroblast Growth Factor-2 and the HIV-1 Tat Protein Synergize in Promoting Bcl-2 Expression and Preventing Endothelial Cell Apoptosis: Implications for the Pathogenesis of AIDS-Associated Kaposi's Sarcoma International Journal of Vascular Medicine |
| title | Fibroblast Growth Factor-2 and the HIV-1 Tat Protein Synergize in Promoting Bcl-2 Expression and Preventing Endothelial Cell Apoptosis: Implications for the Pathogenesis of AIDS-Associated Kaposi's Sarcoma |
| title_full | Fibroblast Growth Factor-2 and the HIV-1 Tat Protein Synergize in Promoting Bcl-2 Expression and Preventing Endothelial Cell Apoptosis: Implications for the Pathogenesis of AIDS-Associated Kaposi's Sarcoma |
| title_fullStr | Fibroblast Growth Factor-2 and the HIV-1 Tat Protein Synergize in Promoting Bcl-2 Expression and Preventing Endothelial Cell Apoptosis: Implications for the Pathogenesis of AIDS-Associated Kaposi's Sarcoma |
| title_full_unstemmed | Fibroblast Growth Factor-2 and the HIV-1 Tat Protein Synergize in Promoting Bcl-2 Expression and Preventing Endothelial Cell Apoptosis: Implications for the Pathogenesis of AIDS-Associated Kaposi's Sarcoma |
| title_short | Fibroblast Growth Factor-2 and the HIV-1 Tat Protein Synergize in Promoting Bcl-2 Expression and Preventing Endothelial Cell Apoptosis: Implications for the Pathogenesis of AIDS-Associated Kaposi's Sarcoma |
| title_sort | fibroblast growth factor 2 and the hiv 1 tat protein synergize in promoting bcl 2 expression and preventing endothelial cell apoptosis implications for the pathogenesis of aids associated kaposi s sarcoma |
| url | http://dx.doi.org/10.1155/2011/452729 |
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