Fibroblast Growth Factor-2 and the HIV-1 Tat Protein Synergize in Promoting Bcl-2 Expression and Preventing Endothelial Cell Apoptosis: Implications for the Pathogenesis of AIDS-Associated Kaposi's Sarcoma

Fibroblast Growth Factor-2 and the HIV-1 Tat Protein Synergize in Promoting Bcl-2 Expression and Preventing Endothelial Cell Apoptosis: Implications for the Pathogenesis of AIDS-Associated Kaposi's Sarcoma

Kaposi's sarcoma (KS) is a vascular tumor frequently occurring in Human Immunodeficiency Virus- (HIV-) 1-infected individuals. Our previous work indicated that the angiogenic fibroblast growth factor (FGF)-2 and the Tat protein of HIV-1, both expressed in KS lesions of HIV-infected patients, sy...

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Main Authors: Cecilia Sgadari, Giovanni Barillari, Clelia Palladino, Stefania Bellino, Brunella Taddeo, Elena Toschi, Barbara Ensoli
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:International Journal of Vascular Medicine
Online Access:http://dx.doi.org/10.1155/2011/452729
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http://dx.doi.org/10.1155/2011/452729

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