Genetic Variations Affect Chemotherapy Outcomes: A Role of the Spindle-assembly Checkpoint
Cancer patients suffer from complicated chemotoxicity. Pharmacogenomics can help stratify patients by predicting their response to treatment and susceptibility toward severe side effects. The spindle-assembly checkpoint (SAC) is an important pathway that is activated by platinum and taxane compounds...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-04-01
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| Series: | Indian Journal of Public Health |
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| Online Access: | https://journals.lww.com/10.4103/ijph.ijph_809_23 |
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| author | Sinjini Sarkar Ranita Pal Trisha Choudhury Manisha Vernekar Partha Nath Vilas D. Nasare |
| author_facet | Sinjini Sarkar Ranita Pal Trisha Choudhury Manisha Vernekar Partha Nath Vilas D. Nasare |
| author_sort | Sinjini Sarkar |
| collection | DOAJ |
| description | Cancer patients suffer from complicated chemotoxicity. Pharmacogenomics can help stratify patients by predicting their response to treatment and susceptibility toward severe side effects. The spindle-assembly checkpoint (SAC) is an important pathway that is activated by platinum and taxane compounds and plays a crucial role in their cytotoxic activity. This study investigated a SAC component, Budding Uninhibited by Benzimidazoles 3 (BUB3), its expression, and genetic variants in advanced ovarian cancer patients treated with paclitaxel–carboplatin chemotherapy. Among 80 patients, BUB3 expression correlated with chemosensitivity, suggesting its potential as a predictive marker for chemotherapy response. However, high BUB3 expression was associated with a higher risk of poor survival. In addition, genetic polymorphisms in BUB3 (rs11248416 and rs11248419) were significantly linked to chemotherapy-related toxicities, with rs11248416 showing a negative impact on the patient’s physical quality of life. |
| format | Article |
| id | doaj-art-755fdc2dd5ef4b1eaa284087b4a98c3f |
| institution | Kabale University |
| issn | 0019-557X 2229-7693 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Public Health |
| spelling | doaj-art-755fdc2dd5ef4b1eaa284087b4a98c3f2025-01-25T05:19:48ZengWolters Kluwer Medknow PublicationsIndian Journal of Public Health0019-557X2229-76932024-04-0168231431710.4103/ijph.ijph_809_23Genetic Variations Affect Chemotherapy Outcomes: A Role of the Spindle-assembly CheckpointSinjini SarkarRanita PalTrisha ChoudhuryManisha VernekarPartha NathVilas D. NasareCancer patients suffer from complicated chemotoxicity. Pharmacogenomics can help stratify patients by predicting their response to treatment and susceptibility toward severe side effects. The spindle-assembly checkpoint (SAC) is an important pathway that is activated by platinum and taxane compounds and plays a crucial role in their cytotoxic activity. This study investigated a SAC component, Budding Uninhibited by Benzimidazoles 3 (BUB3), its expression, and genetic variants in advanced ovarian cancer patients treated with paclitaxel–carboplatin chemotherapy. Among 80 patients, BUB3 expression correlated with chemosensitivity, suggesting its potential as a predictive marker for chemotherapy response. However, high BUB3 expression was associated with a higher risk of poor survival. In addition, genetic polymorphisms in BUB3 (rs11248416 and rs11248419) were significantly linked to chemotherapy-related toxicities, with rs11248416 showing a negative impact on the patient’s physical quality of life.https://journals.lww.com/10.4103/ijph.ijph_809_23budding uninhibited by benzimidazoles 3carboplatinovarian cancerpaclitaxelspindle-assembly checkpoint |
| spellingShingle | Sinjini Sarkar Ranita Pal Trisha Choudhury Manisha Vernekar Partha Nath Vilas D. Nasare Genetic Variations Affect Chemotherapy Outcomes: A Role of the Spindle-assembly Checkpoint Indian Journal of Public Health budding uninhibited by benzimidazoles 3 carboplatin ovarian cancer paclitaxel spindle-assembly checkpoint |
| title | Genetic Variations Affect Chemotherapy Outcomes: A Role of the Spindle-assembly Checkpoint |
| title_full | Genetic Variations Affect Chemotherapy Outcomes: A Role of the Spindle-assembly Checkpoint |
| title_fullStr | Genetic Variations Affect Chemotherapy Outcomes: A Role of the Spindle-assembly Checkpoint |
| title_full_unstemmed | Genetic Variations Affect Chemotherapy Outcomes: A Role of the Spindle-assembly Checkpoint |
| title_short | Genetic Variations Affect Chemotherapy Outcomes: A Role of the Spindle-assembly Checkpoint |
| title_sort | genetic variations affect chemotherapy outcomes a role of the spindle assembly checkpoint |
| topic | budding uninhibited by benzimidazoles 3 carboplatin ovarian cancer paclitaxel spindle-assembly checkpoint |
| url | https://journals.lww.com/10.4103/ijph.ijph_809_23 |
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