Systemic antihyperalgesic effect of a novel conotoxin from Californiconus californicus in an inflammatory pain model
IntroductionThis study explores the analgesic potential of the novel conotoxin O1_cal6.4b, derived from Californiconus californicus, as a candidate for pain management in a model of inflammatory pain.MethodsO1_cal6.4b was systemically administered to Wistar rats, and its effects on thermal hyperalge...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Pain Research |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpain.2024.1500789/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832589846083796992 |
|---|---|
| author | Joaquín López-Carrillo Johanna Bernáldez-Sarabia Tushar J. Pawar Samanta Jiménez Salvador Dueñas Andrea Figueroa-Montiel José L. Olivares-Romero Vinicio Granados-Soto Alexei F. Licea-Navarro Alexei F. Licea-Navarro Nadia L. Caram-Salas Nadia L. Caram-Salas |
| author_facet | Joaquín López-Carrillo Johanna Bernáldez-Sarabia Tushar J. Pawar Samanta Jiménez Salvador Dueñas Andrea Figueroa-Montiel José L. Olivares-Romero Vinicio Granados-Soto Alexei F. Licea-Navarro Alexei F. Licea-Navarro Nadia L. Caram-Salas Nadia L. Caram-Salas |
| author_sort | Joaquín López-Carrillo |
| collection | DOAJ |
| description | IntroductionThis study explores the analgesic potential of the novel conotoxin O1_cal6.4b, derived from Californiconus californicus, as a candidate for pain management in a model of inflammatory pain.MethodsO1_cal6.4b was systemically administered to Wistar rats, and its effects on thermal hyperalgesia and motor coordination were evaluated. Comparative analyses were conducted against O1_cal6.4d, ω-MVIIA, and standard analgesics (morphine, dexamethasone, and diclofenac). Structural differences between O1_cal6.4b and O1_cal6.4d were examined using in silico modeling and molecular dynamics simulations.ResultsSystemic administration of O1_cal6.4b significantly reduced thermal hyperalgesia in a dose-dependent manner without impairing motor coordination. The analgesic effect of O1_cal6.4b was superior to that of O1_cal6.4d, ω-MVIIA, and standard analgesics. Structural analyses revealed notable differences between O1_cal6.4b and O1_cal6.4d, suggesting unique functional properties.DiscussionThe findings indicate that O1_cal6.4b exhibits a promising analgesic profile with advantages over traditional opioid-based therapies. These results underscore the molecular diversity of conotoxins and highlight their potential as innovative analgesic treatments. Further research is needed to elucidate the mechanism of action of this novel conotoxin. |
| format | Article |
| id | doaj-art-6be6ba6a39a94caeb1e9372d3de92ab1 |
| institution | Kabale University |
| issn | 2673-561X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pain Research |
| spelling | doaj-art-6be6ba6a39a94caeb1e9372d3de92ab12025-01-24T07:13:46ZengFrontiers Media S.A.Frontiers in Pain Research2673-561X2025-01-01510.3389/fpain.2024.15007891500789Systemic antihyperalgesic effect of a novel conotoxin from Californiconus californicus in an inflammatory pain modelJoaquín López-Carrillo0Johanna Bernáldez-Sarabia1Tushar J. Pawar2Samanta Jiménez3Salvador Dueñas4Andrea Figueroa-Montiel5José L. Olivares-Romero6Vinicio Granados-Soto7Alexei F. Licea-Navarro8Alexei F. Licea-Navarro9Nadia L. Caram-Salas10Nadia L. Caram-Salas11Departamento de Innovación Biomédica, CICESE, Ensenada, MexicoDepartamento de Innovación Biomédica, CICESE, Ensenada, MexicoRed de Estudios Moleculares Avanzados, Instituto de Ecología (INECOL), Xalapa, MexicoDepartamento de Innovación Biomédica, CICESE, Ensenada, MexicoDepartamento de Innovación Biomédica, CICESE, Ensenada, MexicoDepartamento de Innovación Biomédica, CICESE, Ensenada, MexicoRed de Estudios Moleculares Avanzados, Instituto de Ecología (INECOL), Xalapa, MexicoNeurobiology of Pain Laboratory, Departamento de Farmacobiología, Cinvestav, South Campus, Mexico City, MexicoDepartamento de Innovación Biomédica, CICESE, Ensenada, MexicoDirección de Impulso a la Innovación y el Desarrollo (DIID), CICESE, Ensenada, MexicoDepartamento de Innovación Biomédica, CICESE, Ensenada, MexicoCONAHCYT. Av. Insurgentes Sur 1582, Col. Crédito Constructor, Deleg Benito Juárez, Mexico City, MexicoIntroductionThis study explores the analgesic potential of the novel conotoxin O1_cal6.4b, derived from Californiconus californicus, as a candidate for pain management in a model of inflammatory pain.MethodsO1_cal6.4b was systemically administered to Wistar rats, and its effects on thermal hyperalgesia and motor coordination were evaluated. Comparative analyses were conducted against O1_cal6.4d, ω-MVIIA, and standard analgesics (morphine, dexamethasone, and diclofenac). Structural differences between O1_cal6.4b and O1_cal6.4d were examined using in silico modeling and molecular dynamics simulations.ResultsSystemic administration of O1_cal6.4b significantly reduced thermal hyperalgesia in a dose-dependent manner without impairing motor coordination. The analgesic effect of O1_cal6.4b was superior to that of O1_cal6.4d, ω-MVIIA, and standard analgesics. Structural analyses revealed notable differences between O1_cal6.4b and O1_cal6.4d, suggesting unique functional properties.DiscussionThe findings indicate that O1_cal6.4b exhibits a promising analgesic profile with advantages over traditional opioid-based therapies. These results underscore the molecular diversity of conotoxins and highlight their potential as innovative analgesic treatments. Further research is needed to elucidate the mechanism of action of this novel conotoxin.https://www.frontiersin.org/articles/10.3389/fpain.2024.1500789/fullconotoxin systemic administrationCaliforniconus californicuschronic pain treatmentsanalgesiainflammatory pain |
| spellingShingle | Joaquín López-Carrillo Johanna Bernáldez-Sarabia Tushar J. Pawar Samanta Jiménez Salvador Dueñas Andrea Figueroa-Montiel José L. Olivares-Romero Vinicio Granados-Soto Alexei F. Licea-Navarro Alexei F. Licea-Navarro Nadia L. Caram-Salas Nadia L. Caram-Salas Systemic antihyperalgesic effect of a novel conotoxin from Californiconus californicus in an inflammatory pain model Frontiers in Pain Research conotoxin systemic administration Californiconus californicus chronic pain treatments analgesia inflammatory pain |
| title | Systemic antihyperalgesic effect of a novel conotoxin from Californiconus californicus in an inflammatory pain model |
| title_full | Systemic antihyperalgesic effect of a novel conotoxin from Californiconus californicus in an inflammatory pain model |
| title_fullStr | Systemic antihyperalgesic effect of a novel conotoxin from Californiconus californicus in an inflammatory pain model |
| title_full_unstemmed | Systemic antihyperalgesic effect of a novel conotoxin from Californiconus californicus in an inflammatory pain model |
| title_short | Systemic antihyperalgesic effect of a novel conotoxin from Californiconus californicus in an inflammatory pain model |
| title_sort | systemic antihyperalgesic effect of a novel conotoxin from californiconus californicus in an inflammatory pain model |
| topic | conotoxin systemic administration Californiconus californicus chronic pain treatments analgesia inflammatory pain |
| url | https://www.frontiersin.org/articles/10.3389/fpain.2024.1500789/full |
| work_keys_str_mv | AT joaquinlopezcarrillo systemicantihyperalgesiceffectofanovelconotoxinfromcaliforniconuscalifornicusinaninflammatorypainmodel AT johannabernaldezsarabia systemicantihyperalgesiceffectofanovelconotoxinfromcaliforniconuscalifornicusinaninflammatorypainmodel AT tusharjpawar systemicantihyperalgesiceffectofanovelconotoxinfromcaliforniconuscalifornicusinaninflammatorypainmodel AT samantajimenez systemicantihyperalgesiceffectofanovelconotoxinfromcaliforniconuscalifornicusinaninflammatorypainmodel AT salvadorduenas systemicantihyperalgesiceffectofanovelconotoxinfromcaliforniconuscalifornicusinaninflammatorypainmodel AT andreafigueroamontiel systemicantihyperalgesiceffectofanovelconotoxinfromcaliforniconuscalifornicusinaninflammatorypainmodel AT joselolivaresromero systemicantihyperalgesiceffectofanovelconotoxinfromcaliforniconuscalifornicusinaninflammatorypainmodel AT viniciogranadossoto systemicantihyperalgesiceffectofanovelconotoxinfromcaliforniconuscalifornicusinaninflammatorypainmodel AT alexeifliceanavarro systemicantihyperalgesiceffectofanovelconotoxinfromcaliforniconuscalifornicusinaninflammatorypainmodel AT alexeifliceanavarro systemicantihyperalgesiceffectofanovelconotoxinfromcaliforniconuscalifornicusinaninflammatorypainmodel AT nadialcaramsalas systemicantihyperalgesiceffectofanovelconotoxinfromcaliforniconuscalifornicusinaninflammatorypainmodel AT nadialcaramsalas systemicantihyperalgesiceffectofanovelconotoxinfromcaliforniconuscalifornicusinaninflammatorypainmodel |