LIN28B expression is downregulated in mature spermatozoa of oligozoospermic men and associates with genetic variants previously linked to pubertal onset

LIN28B expression is downregulated in mature spermatozoa of oligozoospermic men and associates with genetic variants previously linked to pubertal onset

LIN28B is an RNA-binding protein that acts as a post-transcriptional regulator of genes involved in developmental timing and self-renewal through its interaction with let-7 miRNAs. Large-scale genomic studies have strongly implicated SNPs in LIN28B with male puberty timing. In addition, the occurren...

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Bibliographic Details
Main Authors: María Cecilia Lardone, Marina Díaz-Fontdevila, Eliana Ortiz, Germán Iñiguez, Pamela Inostroza, Cristóbal Espinoza, Mauricio Ebensperger, Kristian Almstrup, Andrea Castro
Format: Article
Language:English
Published: Bioscientifica 2025-05-01
Series:Endocrine Connections
Subjects:
lin28b
mirna let-7
oligozoospermia
lin28b genetic polymorphisms
male infertility
male puberty
Online Access:https://ec.bioscientifica.com/view/journals/ec/14/6/EC-25-0044.xml
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