LIN28B expression is downregulated in mature spermatozoa of oligozoospermic men and associates with genetic variants previously linked to pubertal onset

LIN28B is an RNA-binding protein that acts as a post-transcriptional regulator of genes involved in developmental timing and self-renewal through its interaction with let-7 miRNAs. Large-scale genomic studies have strongly implicated SNPs in LIN28B with male puberty timing. In addition, the occurren...

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Main Authors: María Cecilia Lardone, Marina Díaz-Fontdevila, Eliana Ortiz, Germán Iñiguez, Pamela Inostroza, Cristóbal Espinoza, Mauricio Ebensperger, Kristian Almstrup, Andrea Castro
Format: Article
Language:English
Published: Bioscientifica 2025-05-01
Series:Endocrine Connections
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Online Access:https://ec.bioscientifica.com/view/journals/ec/14/6/EC-25-0044.xml
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