Reconstruction of Exposure to m-Xylene from Human Biomonitoring Data Using PBPK Modelling, Bayesian Inference, and Markov Chain Monte Carlo Simulation

Reconstruction of Exposure to m-Xylene from Human Biomonitoring Data Using PBPK Modelling, Bayesian Inference, and Markov Chain Monte Carlo Simulation

There are numerous biomonitoring programs, both recent and ongoing, to evaluate environmental exposure of humans to chemicals. Due to the lack of exposure and kinetic data, the correlation of biomarker levels with exposure concentrations leads to difficulty in utilizing biomonitoring data for biolog...

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Bibliographic Details
Main Authors: Kevin McNally, Richard Cotton, John Cocker, Kate Jones, Mike Bartels, David Rick, Paul Price, George Loizou
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Journal of Toxicology
Online Access:http://dx.doi.org/10.1155/2012/760281
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