Regulation of TXB2 and PGE2 production by TGF-β1 in in vitro silica dust-exposed rat alveolar macrophage
We investigated the effect of transforming factor factor-β1 (TGF-β1) on thromboxane B2 (TXB2) and prostaglandin E2 (PGE2) production in in vitro silica dust-exposed rat alveolar macrophages (AM). In the presence of 5 μg of anti-TGF-β1 antibodies, TXB2 production decreased, but PGE2 production increa...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1995-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935195000664 |
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| Summary: | We investigated the effect of transforming factor factor-β1 (TGF-β1) on thromboxane B2 (TXB2) and prostaglandin E2 (PGE2) production in in vitro silica dust-exposed rat alveolar macrophages (AM). In the presence of 5 μg of anti-TGF-β1 antibodies, TXB2 production decreased, but PGE2 production increased. Addition of 2 ng of TGF-β1 to the culture medium potentiated TXB2 production, but PGE2 production apparently did not change. At 50 ng of TGF-β1, TXB2 production decreased, and PGE2 production varied. Our data suggest that in rat AM: (1) both endogenous and exogenous TGF-β1 regulate TXB2 production; and (2) in the absence of endogenous TGF-β1 the liberation of PGE2 increases; however, exogenous TGF-β1 does not have a regulatory effect on PGE2. |
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| ISSN: | 0962-9351 1466-1861 |