Roles of core fucosylation modification in immune system and diseases
Core fucosylation, catalyzed by α1,6-fucosyltransferase (FUT8), is an important N-glycosylation modification process that attaches a fucose residue via an α1,6-linkage to the core N-acetylglucosamine of N-glycans in mammals. Research over the past three decades has revealed the critical role of FUT8...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Cell Insight |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S277289272400066X |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832582138605600768 |
|---|---|
| author | Qiu Pan Xiao-Lian Zhang |
| author_facet | Qiu Pan Xiao-Lian Zhang |
| author_sort | Qiu Pan |
| collection | DOAJ |
| description | Core fucosylation, catalyzed by α1,6-fucosyltransferase (FUT8), is an important N-glycosylation modification process that attaches a fucose residue via an α1,6-linkage to the core N-acetylglucosamine of N-glycans in mammals. Research over the past three decades has revealed the critical role of FUT8-mediated core fucosylation modification in various physiological and pathological processes, including cell growth, adhesion, receptor activation, antibody-dependent cellular cytotoxicity (ADCC), tumor metastasis and infections. This review discusses the immune system function involving FUT8 and the mechanisms by which core fucosylation regulates immunity and contributes to disease. A deeper understanding of these mechanisms can provide insights into cellular biology and suggest new therapeutic approaches and targets for related diseases. |
| format | Article |
| id | doaj-art-ffca561f2cf0491aa84cfd1d8fdd5edb |
| institution | Kabale University |
| issn | 2772-8927 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Insight |
| spelling | doaj-art-ffca561f2cf0491aa84cfd1d8fdd5edb2025-01-30T05:15:17ZengElsevierCell Insight2772-89272025-02-0141100211Roles of core fucosylation modification in immune system and diseasesQiu Pan0Xiao-Lian Zhang1Hubei Province Key Laboratory of Allergy and Immunology, Department of Allergy Zhongnan Hospital of Wuhan University, Department of Immunology Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan, 430071, China; State Key Laboratory of Virology, Frontier Science Center for Immunology and Metabolism, Wuhan University School of Medicine, Wuhan, 430071, ChinaHubei Province Key Laboratory of Allergy and Immunology, Department of Allergy Zhongnan Hospital of Wuhan University, Department of Immunology Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan, 430071, China; State Key Laboratory of Virology, Frontier Science Center for Immunology and Metabolism, Wuhan University School of Medicine, Wuhan, 430071, China; Corresponding author. Hubei Province Key Laboratory of Allergy and Immunology, Department of Allergy Zhongnan Hospital of Wuhan University, Department of Immunology Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan, China.Core fucosylation, catalyzed by α1,6-fucosyltransferase (FUT8), is an important N-glycosylation modification process that attaches a fucose residue via an α1,6-linkage to the core N-acetylglucosamine of N-glycans in mammals. Research over the past three decades has revealed the critical role of FUT8-mediated core fucosylation modification in various physiological and pathological processes, including cell growth, adhesion, receptor activation, antibody-dependent cellular cytotoxicity (ADCC), tumor metastasis and infections. This review discusses the immune system function involving FUT8 and the mechanisms by which core fucosylation regulates immunity and contributes to disease. A deeper understanding of these mechanisms can provide insights into cellular biology and suggest new therapeutic approaches and targets for related diseases.http://www.sciencedirect.com/science/article/pii/S277289272400066XCore fucosylationFUT8Immune systemDisease |
| spellingShingle | Qiu Pan Xiao-Lian Zhang Roles of core fucosylation modification in immune system and diseases Cell Insight Core fucosylation FUT8 Immune system Disease |
| title | Roles of core fucosylation modification in immune system and diseases |
| title_full | Roles of core fucosylation modification in immune system and diseases |
| title_fullStr | Roles of core fucosylation modification in immune system and diseases |
| title_full_unstemmed | Roles of core fucosylation modification in immune system and diseases |
| title_short | Roles of core fucosylation modification in immune system and diseases |
| title_sort | roles of core fucosylation modification in immune system and diseases |
| topic | Core fucosylation FUT8 Immune system Disease |
| url | http://www.sciencedirect.com/science/article/pii/S277289272400066X |
| work_keys_str_mv | AT qiupan rolesofcorefucosylationmodificationinimmunesystemanddiseases AT xiaolianzhang rolesofcorefucosylationmodificationinimmunesystemanddiseases |