Combination astragaloside IV and artesunate preserves blood–brain barrier integrity by modulating astrocytes and tight junction proteins in Plasmodium yoelii infection

Combination astragaloside IV and artesunate preserves blood–brain barrier integrity by modulating astrocytes and tight junction proteins in Plasmodium yoelii infection

Background: Astragaloside IV (ASIV), a natural compound from Astragalus membranaceus, exerts neuroprotective and anti-inflammatory effects in various pathologies. Its role in Plasmodium yoelii (Py) 17XL–induced inflammation leading to blood–brain barrier (BBB) damage remains undefined. Artesunate (A...

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Main Authors: Phornyupa Sanguanwong, Ladawan Khowawisetsut, Lanaprai Kwathai, Peeraporn Varinthra, Chairat Turbpaiboon, Panapat Uawithya, Prasert Sobhon, Ingrid Y. Liu, Supin Chompoopong
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Aquaporin-4
Astragaloside IV
Astrocytic glial fibrillary acidic protein
Plasmodium yoelii
Tight junction protein
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320725000211
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