DrFARM: identification of pleiotropic genetic variants in genome-wide association studies

Abstract In a standard analysis, pleiotropic variants are identified by running separate genome-wide association studies (GWAS) and combining results across traits. But such statistical approach based on marginal summary statistics may lead to spurious results. We propose a new statistical approach,...

Full description

Saved in:
Bibliographic Details
Main Authors: Lap Sum Chan, Gen Li, Eric B. Fauman, Xianyong Yin, Markku Laakso, Michael Boehnke, Peter X. K. Song
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60439-4
Tags: Add Tag
No Tags, Be the first to tag this record!