Hyaluronidases improve the hyaluronic acid yield during the fermentation of Streptococcus zooepidemicus

Hyaluronidases improve the hyaluronic acid yield during the fermentation of Streptococcus zooepidemicus

BackgroundHyaluronic acid (HA), a linear acidic mucopolysaccharide with exceptional biocompatibility, is extensively utilized in pharmaceuticals and cosmetics. Industrial HA production predominantly relies on Streptococcus zooepidemicus fermentation. However, the accumulation of high-molecular-weigh...

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Main Authors: Chuan-Li Kang, De-Qiang Zheng, Zhi-Yuan Yao, Kang Yang, Yuxue Zhao, Zihan Mao, Yang Liu, Haijun Li, Jin-Song Gong, Lei Liu, Qingwen Jia, Zheng-Hong Xu, Jin-Song Shi, Le Xue
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
hyaluronidases
hyaluronic acid
enzymatic fermentation
protein expression
fermentation process optimization
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1625009/full
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https://www.frontiersin.org/articles/10.3389/fbioe.2025.1625009/full

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