The effect of zopiclone co-administration on sertraline initial dosage optimization in pediatric major depressive disorder patients based on model-informed precision dosing

The effect of zopiclone co-administration on sertraline initial dosage optimization in pediatric major depressive disorder patients based on model-informed precision dosing

ObjectiveThe present study aims to explore the initial dosage optimization of sertraline in pediatric major depressive disorder (MDD) patients based on model-informed precision dosing (MIPD).MethodsA total of 111 pediatric MDD patients treated with sertraline were included for analysis using MIPD. S...

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Bibliographic Details
Main Authors: Xiao Chen, Ke Hu, Hao-Zhe Shi, Su-Mei He, Yang Yang, Chao-Wen Yang, Yue Zhang, Xue Tian, Ye Li, Yu-Hang Gao, Wen-Yi Xu, Cun Zhang, Dong-Dong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
zopiclone
sertraline
initial dosage optimization
pediatric major depressive disorder
model-informed precision dosing
drug-drug interaction
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1470865/full
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https://www.frontiersin.org/articles/10.3389/fphar.2024.1470865/full

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