Three-dimensional single-cell transcriptome imaging of thick tissues

Three-dimensional single-cell transcriptome imaging of thick tissues

Multiplexed error-robust fluorescence in situ hybridization (MERFISH) allows genome-scale imaging of RNAs in individual cells in intact tissues. To date, MERFISH has been applied to image thin-tissue samples of ~10 µm thickness. Here, we present a thick-tissue three-dimensional (3D) MERFISH imaging...

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Bibliographic Details
Main Authors: Rongxin Fang, Aaron Halpern, Mohammed Mostafizur Rahman, Zhengkai Huang, Zhiyun Lei, Sebastian J Hell, Catherine Dulac, Xiaowei Zhuang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
spatial genomics
MERFISH
brain
genome-scale imaging
thick-tissue imaging
spatial transcriptomics
Online Access:https://elifesciences.org/articles/90029
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https://elifesciences.org/articles/90029

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