A Mathematical Model of Receptor-Mediated Apoptosis: Dying to Know Why FasL is a Trimer
The scientific importance of understanding programmed cell death isundeniable; however, the complexity of death signal propagation andthe formerly incomplete knowledge of apoptotic pathways has left thistopic virtually untouched by mathematical modeling. In this paper, weuse a mechanistic approach...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
AIMS Press
2004-06-01
|
| Series: | Mathematical Biosciences and Engineering |
| Subjects: | |
| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2004.1.325 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832590301138518016 |
|---|---|
| author | Ronald Lai Trachette L. Jackson |
| author_facet | Ronald Lai Trachette L. Jackson |
| author_sort | Ronald Lai |
| collection | DOAJ |
| description | The scientific importance of understanding programmed cell death isundeniable; however, the complexity of death signal propagation andthe formerly incomplete knowledge of apoptotic pathways has left thistopic virtually untouched by mathematical modeling. In this paper, weuse a mechanistic approach to frame the current understanding ofreceptor-mediated apoptosis with an immediate goal of isolating therole receptor trimerization plays in this process. Analysis andsimulation suggest that if the death signal is to be successful at low-receptor, high-ligand concentration, Fas trimerization is unlikely tobe the driving force in the signal propagation. However at high-receptor and low-ligand concentrations, the mathematical modelillustrates how the ability of FasL to cluster three Fas receptors canbe crucially important for downstream events that propagate theapoptotic signal. |
| format | Article |
| id | doaj-art-ff451c4e735140c3b2ccfc620abdf1ad |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2004-06-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-ff451c4e735140c3b2ccfc620abdf1ad2025-01-24T01:46:53ZengAIMS PressMathematical Biosciences and Engineering1551-00182004-06-011232533810.3934/mbe.2004.1.325A Mathematical Model of Receptor-Mediated Apoptosis: Dying to Know Why FasL is a TrimerRonald Lai0Trachette L. Jackson1Department of Mathematics, University of Michigan, 525 E. University, Ann Arbor, Mi 48109-1109Department of Mathematics, University of Michigan, 525 E. University, Ann Arbor, Mi 48109-1109The scientific importance of understanding programmed cell death isundeniable; however, the complexity of death signal propagation andthe formerly incomplete knowledge of apoptotic pathways has left thistopic virtually untouched by mathematical modeling. In this paper, weuse a mechanistic approach to frame the current understanding ofreceptor-mediated apoptosis with an immediate goal of isolating therole receptor trimerization plays in this process. Analysis andsimulation suggest that if the death signal is to be successful at low-receptor, high-ligand concentration, Fas trimerization is unlikely tobe the driving force in the signal propagation. However at high-receptor and low-ligand concentrations, the mathematical modelillustrates how the ability of FasL to cluster three Fas receptors canbe crucially important for downstream events that propagate theapoptotic signal.https://www.aimspress.com/article/doi/10.3934/mbe.2004.1.325caspase activation.fas/faslapoptosis |
| spellingShingle | Ronald Lai Trachette L. Jackson A Mathematical Model of Receptor-Mediated Apoptosis: Dying to Know Why FasL is a Trimer Mathematical Biosciences and Engineering caspase activation. fas/fasl apoptosis |
| title | A Mathematical Model of Receptor-Mediated Apoptosis: Dying to Know Why FasL is a Trimer |
| title_full | A Mathematical Model of Receptor-Mediated Apoptosis: Dying to Know Why FasL is a Trimer |
| title_fullStr | A Mathematical Model of Receptor-Mediated Apoptosis: Dying to Know Why FasL is a Trimer |
| title_full_unstemmed | A Mathematical Model of Receptor-Mediated Apoptosis: Dying to Know Why FasL is a Trimer |
| title_short | A Mathematical Model of Receptor-Mediated Apoptosis: Dying to Know Why FasL is a Trimer |
| title_sort | mathematical model of receptor mediated apoptosis dying to know why fasl is a trimer |
| topic | caspase activation. fas/fasl apoptosis |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2004.1.325 |
| work_keys_str_mv | AT ronaldlai amathematicalmodelofreceptormediatedapoptosisdyingtoknowwhyfaslisatrimer AT trachetteljackson amathematicalmodelofreceptormediatedapoptosisdyingtoknowwhyfaslisatrimer AT ronaldlai mathematicalmodelofreceptormediatedapoptosisdyingtoknowwhyfaslisatrimer AT trachetteljackson mathematicalmodelofreceptormediatedapoptosisdyingtoknowwhyfaslisatrimer |