Germline prediction of immune checkpoint inhibitor discontinuation for immune-related adverse events

Germline prediction of immune checkpoint inhibitor discontinuation for immune-related adverse events

Introduction Immune checkpoint inhibitors (ICIs) can yield remarkable clinical responses in subsets of patients with solid tumors, but they also commonly cause immune-related adverse events (irAEs). The predictive features of clinically severe irAEs leading to cessation of ICIs have yet to be establ...

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Main Authors: Min Li, Geoffrey Liu, Elad Ziv, Rohit Thummalapalli, Adam Schoenfeld, Melinda C Aldrich, Scott Huntsman, Zoe Quandt, Christine M Lovly, Pooja Middha, Karmugi Balaratnam, Eduardo Cardenas, Christina J Falcon, Princess Margaret Lung Group, Matthew A Gubens, Khaleeq Khan, Devalben Patel, Luna Jia Zhan
Format: Article
Language:English
Published: BMJ Publishing Group 2025-03-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/3/e011273.full
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https://jitc.bmj.com/content/13/3/e011273.full

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