Machine learning derived retinal pigment score from ophthalmic imaging shows ethnicity is not biology

Machine learning derived retinal pigment score from ophthalmic imaging shows ethnicity is not biology

Abstract Few metrics exist to describe phenotypic diversity within ophthalmic imaging datasets, with researchers often using ethnicity as a surrogate marker for biological variability. We derived a continuous, measured metric, the retinal pigment score (RPS), that quantifies the degree of pigmentati...

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Main Authors: Anand E. Rajesh, Abraham Olvera-Barrios, Alasdair N. Warwick, Yue Wu, Kelsey V. Stuart, Mahantesh I. Biradar, Chuin Ying Ung, Anthony P. Khawaja, Robert Luben, Paul J. Foster, Charles R. Cleland, William U. Makupa, Alastair K. Denniston, Matthew J. Burton, Andrew Bastawrous, Pearse A. Keane, Mark A. Chia, Angus W. Turner, Cecilia S. Lee, Adnan Tufail, Aaron Y. Lee, Catherine Egan, UK Biobank Eye and Vision Consortium
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55198-7
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https://doi.org/10.1038/s41467-024-55198-7

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