Bisecting GlcNAc modification of vesicular GAS6 regulates CAFs activation and breast cancer metastasis

Bisecting GlcNAc modification of vesicular GAS6 regulates CAFs activation and breast cancer metastasis

Abstract Background Cancer-associated fibroblasts (CAFs) are a pivotal component of the tumor microenvironment (TME), playing key roles in tumor initiation, metastasis, and chemoresistance. While glycosylation is known to regulate various cellular processes, its impact on CAFs activation remains ins...

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Main Authors: Jing Li, Xueting Ren, Lin Cao, Kaixiang Min, Meng Wang, Shuai Lin, Lei Lei, Zengqi Tan, Xiaoliang Cheng, Xiang Li, Feng Guan
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cell Communication and Signaling
Subjects:
Breast cancer
Bisecting GlcNAc
Cancer-associated fibroblasts
GAS6
Small extracellular vesicles
Online Access:https://doi.org/10.1186/s12964-025-02052-y
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https://doi.org/10.1186/s12964-025-02052-y

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