Elucidation of Mechanism of Action in Drug Invention: Using Stable Isotope Tracers to Unravel Biochemical Kinetics

Elucidation of Mechanism of Action in Drug Invention: Using Stable Isotope Tracers to Unravel Biochemical Kinetics

ABSTRACT The invention of a therapeutic begins by characterizing features that differentiate healthy versus diseased states; this often presents as changes in the concentration of an analyte. Examples include elevated blood glucose in diabetes, high cholesterol in heart disease, and protein aggregat...

Full description

Saved in:
Bibliographic Details
Main Authors: Rebecca A. Kohnz, Dan Zhou, Bin Lou, Huifang Yao, David McKenney, Dhiraj Dokwal, Ruth Villanueva, Heidi Kocalis, Jeanine E. Ballard, Jennifer Piesvaux, Stephen F. Previs
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Pharmacology Research & Perspectives
Subjects:
biochemical pathway
drug discovery
isotope tracers
mass spectrometry
metabolic activity
organ crosstalk
Online Access:https://doi.org/10.1002/prp2.70099
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1002/prp2.70099

Similar Items