CD4 T cell counts are inversely correlated with anti-gp120 cluster A antibodies in antiretroviral therapy-treated PLWHResearch in context

CD4 T cell counts are inversely correlated with anti-gp120 cluster A antibodies in antiretroviral therapy-treated PLWHResearch in context

Summary: Background: While antiretroviral therapy (ART) efficiently suppresses viral replication, inflammation and immune dysfunction persist in some people living with HIV-1 (PLWH). HIV-1 soluble gp120 (sgp120) has been detected in PLWH plasma and its presence is linked to immune dysfunction. It w...

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Main Authors: Mehdi Benlarbi, Jonathan Richard, Tommaso Clemente, Catherine Bourassa, William D. Tolbert, Suneetha Gottumukkala, Marc Messier-Peet, Halima Medjahed, Marzena Pazgier, Frank Maldarelli, Antonella Castagna, Madeleine Durand, Andrés Finzi
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:EBioMedicine
Subjects:
HIV
CD4+ T cells depletion
Soluble gp120
CD4 binding site antibodies
Anti-cluster A antibodies
ADCC
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425003007
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