Adipocyte-derived factors induce adherent to suspension transition in breast and pancreatic cancer cells through lipid metabolic alteration

Adipocyte-derived factors induce adherent to suspension transition in breast and pancreatic cancer cells through lipid metabolic alteration

Abstract Adipocytes play a dynamic role in the tumor microenvironment (TME) by acting as facilitators, providing cytokines and metabolites that regulate cancer progression and metastasis. Despite metastasis being a major contributor to cancer-associated mortality, our understanding of how adipocytes...

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Bibliographic Details
Main Authors: Doru Kwon, Hyun Woo Park, Byung Soh Min, Junjeong Choi
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Circulating tumor cell
AST
Tumor microenvironment
Adipocytes
Lipid metabolism
CD36
Online Access:https://doi.org/10.1038/s41598-025-13309-4
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