Predictors of treatment REsponse to inhaled corticosteroids (ICS) in Chronic Obstructive pulmonary disease: randomised controlled trials individual participant Data re-Evaluation–protocol of the ICS-RECODE individual participant data meta-analysis

Introduction Inhaled corticosteroids (ICS) can improve clinical outcomes in patients with chronic obstructive pulmonary disease (COPD) and eosinophilic airway inflammation, but they also increase the risk of side effects like pneumonia. Blood eosinophils guide ICS use, though evidence is limited. Th...

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Main Authors: Matthew Sperrin, John R Hurst, Michael Miligkos, Joergen Vestbo, Pradeesh Sivapalan, Mike Clarke, Lesley Stewart, Jørgen Vestbo, Dave Singh, Tim Felton, Alexander G Mathioudakis, Rebecca Fortescue, Jennifer Quint, Jonathan Marshall, Anurita Majumdar, Jan Hansel, Alice M Turner, Sinduja Manohar, Catherine Fullwood, Nawar Diar Bakerly, Mark Simmonds, Steven Barnes, Ashley Woodcock, Sebastian Bate, Jens-Ulrik Jensen, Markus Fally, Helen Ashdown, Ashley A Woodcock, Emily Howlett, John Linnell, Alan Preston, Glauco Cappellini, Dmitry Galkin, Olaf Joens
Format: Article
Language:English
Published: BMJ Publishing Group 2025-03-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/3/e095541.full
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