Chronic exposure to environmental concentrations of 6PPDQ induces neurotoxicity via perturbing multiple neurotransmission pathways in zebrafish

Chronic exposure to environmental concentrations of 6PPDQ induces neurotoxicity via perturbing multiple neurotransmission pathways in zebrafish

Previous research has demonstrated acute toxicity of 6PPD-quinone (6PPDQ), the ozonation product of tire-manufacturing additive 6PPD; however, chronic effects on aquatic organisms under real-world conditions remain unclear. We exposed 2-month-old zebrafish to 6PPDQ at concentrations of 2, 20 and 200...

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Bibliographic Details
Main Authors: Chuan Yi, Chunyan Xu, Pan Gao, Hengtao Wang, Yao Dang, Song Hou, Ruowen Zhang, Mingdeng Xiang
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Environment International
Subjects:
6PPDQ
Zebrafish
Mass spectrometry imaging
Neurotoxicity
Neurotransmitter
Molecular mechanism
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412025003307
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