UFMTrack, an Under-Flow Migration Tracker enabling analysis of the entire multi-step immune cell extravasation cascade across the blood-brain barrier in microfluidic devices

UFMTrack, an Under-Flow Migration Tracker enabling analysis of the entire multi-step immune cell extravasation cascade across the blood-brain barrier in microfluidic devices

The endothelial blood-brain barrier (BBB) strictly controls immune cell trafficking into the central nervous system (CNS). In neuroinflammatory diseases such as multiple sclerosis, this tight control is, however, disturbed, leading to immune cell infiltration into the CNS. The development of in vitr...

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Bibliographic Details
Main Authors: Mykhailo Vladymyrov, Luca Marchetti, Sidar Aydin, Sasha GN Soldati, Adrien Mossu, Arindam Pal, Laurent Gueissaz, Akitaka Ariga, Britta Engelhardt
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
leukocyte trafficking
blood-brain barrier
cell tracking under flow
automated analysis
machine learning
microfluidics
Online Access:https://elifesciences.org/articles/91150
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https://elifesciences.org/articles/91150

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