Diverse cell types establish a pathogenic immune environment in peripheral neuropathy

Diverse cell types establish a pathogenic immune environment in peripheral neuropathy

Abstract Neuroinflammation plays a complex and context-dependent role in many neurodegenerative diseases. We identified a key pathogenic function of macrophages in a mouse model of a rare human congenital neuropathy in which SARM1, the central executioner of axon degeneration, is activated by hypomo...

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Bibliographic Details
Main Authors: Julie Choi, Amy Strickland, Hui Qi Loo, Wendy Dong, Lilianne Barbar, A. Joseph Bloom, Yo Sasaki, Sheng Chih Jin, Aaron DiAntonio, Jeffrey Milbrandt
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Neuroinflammation
Subjects:
SARM1
NMNAT2
Sarmopathy
Nerve-resident cells
Endoneurial fibroblasts
Repair Schwann cells
Online Access:https://doi.org/10.1186/s12974-025-03459-7
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https://doi.org/10.1186/s12974-025-03459-7

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