Verbascoside exerts an anti-atherosclerotic effect by regulating liver glycerophospholipid metabolism
Verbascoside, abundant in olive mill wastewater, is a phenylethanolic glycoside with a wide range of pharmacological activities. Atherosclerosis (AS) is a common metabolic disease and abnormal lipid metabolism in liver is inseparable from its formation and development. In this study, the anti-athero...
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Tsinghua University Press
2023-11-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023000873 |
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| author | Peng Lei Jialin Lü Tie Yao Peng Zhang Xin Chai Yuefei Wang Miaomiao Jiang |
| author_facet | Peng Lei Jialin Lü Tie Yao Peng Zhang Xin Chai Yuefei Wang Miaomiao Jiang |
| author_sort | Peng Lei |
| collection | DOAJ |
| description | Verbascoside, abundant in olive mill wastewater, is a phenylethanolic glycoside with a wide range of pharmacological activities. Atherosclerosis (AS) is a common metabolic disease and abnormal lipid metabolism in liver is inseparable from its formation and development. In this study, the anti-atherosclerotic effect of verbascoside was evaluated by establishing an atherosclerosis model based on western diet feeding of apolipoprotein E-deficient mice for 16 weeks. After 12 weeks of administration during the feeding period, the levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) in the plasma of mice were significantly decreased, the formation of arterial plaques was delayed, and the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) in plasma were alleviated, showing the hepatoprotective effect. In addition, based on untargeted lipidomic analysis, verbascoside stabilized glycerophospholipid metabolism, modulated lipid metabolism disorders and reduced lipid deposition in the liver to achieve the therapeutic efficacy against atherosclerosis by regulating cardiolipin (CL), ether-linked phosphatidylcholine (ether-PC), lysophophatidylcholine (LPC), phosphatidylcholine (PC), oxidized phosphatidylcholine (OxPC), oxidized phosphatidylethanolamine (OxPE), triacylglycerol (TG), sphingomyelin (SM) back to normal levels. |
| format | Article |
| id | doaj-art-fdc1edfe8963433399b3be8c3865865f |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-fdc1edfe8963433399b3be8c3865865f2025-02-03T02:42:14ZengTsinghua University PressFood Science and Human Wellness2213-45302023-11-0112623142323Verbascoside exerts an anti-atherosclerotic effect by regulating liver glycerophospholipid metabolismPeng Lei0Jialin Lü1Tie Yao2Peng Zhang3Xin Chai4Yuefei Wang5Miaomiao Jiang6State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaState Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaState Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaState Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaState Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaState Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaState Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Corresponding author at: State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.Verbascoside, abundant in olive mill wastewater, is a phenylethanolic glycoside with a wide range of pharmacological activities. Atherosclerosis (AS) is a common metabolic disease and abnormal lipid metabolism in liver is inseparable from its formation and development. In this study, the anti-atherosclerotic effect of verbascoside was evaluated by establishing an atherosclerosis model based on western diet feeding of apolipoprotein E-deficient mice for 16 weeks. After 12 weeks of administration during the feeding period, the levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) in the plasma of mice were significantly decreased, the formation of arterial plaques was delayed, and the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) in plasma were alleviated, showing the hepatoprotective effect. In addition, based on untargeted lipidomic analysis, verbascoside stabilized glycerophospholipid metabolism, modulated lipid metabolism disorders and reduced lipid deposition in the liver to achieve the therapeutic efficacy against atherosclerosis by regulating cardiolipin (CL), ether-linked phosphatidylcholine (ether-PC), lysophophatidylcholine (LPC), phosphatidylcholine (PC), oxidized phosphatidylcholine (OxPC), oxidized phosphatidylethanolamine (OxPE), triacylglycerol (TG), sphingomyelin (SM) back to normal levels.http://www.sciencedirect.com/science/article/pii/S2213453023000873AtherosclerosisVerbascosideLipid depositionLipidomicsGlycerophospholipid metabolism |
| spellingShingle | Peng Lei Jialin Lü Tie Yao Peng Zhang Xin Chai Yuefei Wang Miaomiao Jiang Verbascoside exerts an anti-atherosclerotic effect by regulating liver glycerophospholipid metabolism Food Science and Human Wellness Atherosclerosis Verbascoside Lipid deposition Lipidomics Glycerophospholipid metabolism |
| title | Verbascoside exerts an anti-atherosclerotic effect by regulating liver glycerophospholipid metabolism |
| title_full | Verbascoside exerts an anti-atherosclerotic effect by regulating liver glycerophospholipid metabolism |
| title_fullStr | Verbascoside exerts an anti-atherosclerotic effect by regulating liver glycerophospholipid metabolism |
| title_full_unstemmed | Verbascoside exerts an anti-atherosclerotic effect by regulating liver glycerophospholipid metabolism |
| title_short | Verbascoside exerts an anti-atherosclerotic effect by regulating liver glycerophospholipid metabolism |
| title_sort | verbascoside exerts an anti atherosclerotic effect by regulating liver glycerophospholipid metabolism |
| topic | Atherosclerosis Verbascoside Lipid deposition Lipidomics Glycerophospholipid metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023000873 |
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