Short-Time Intermittent Preexposure of Living Human Donors to Hyperoxia Improves Renal Function in Early Posttransplant Period: A Double-Blind Randomized Clinical Trial
The purpose of this human study was to investigate the effect of oxygen pretreatment in living kidney donors on early renal function of transplanted kidney. Sixty living kidney donor individuals were assigned to receive either 8–10 L/min oxygen (Group I) by a non-rebreather mask with reservoir bag i...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2011/204843 |
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| author | Kamran Montazeri Mohammadali Vakily Azim Honarmand Parviz Kashefi Mohammadreza Safavi Shahram Taheri Bahram Rasoulian |
| author_facet | Kamran Montazeri Mohammadali Vakily Azim Honarmand Parviz Kashefi Mohammadreza Safavi Shahram Taheri Bahram Rasoulian |
| author_sort | Kamran Montazeri |
| collection | DOAJ |
| description | The purpose of this human study was to investigate the effect of oxygen pretreatment in living kidney donors on early renal function of transplanted kidney. Sixty living kidney donor individuals were assigned to receive either 8–10 L/min oxygen (Group I) by a non-rebreather mask with reservoir bag intermittently for one hour at four times (20, 16, 12, and 1 hours before transplantation) or air (Group II). After kidney transplantation, urine output, blood urea nitrogen (BUN), serum creatinine, need to additional diuretics (NTADs) in the first 24 hours after transplantation, delayed graft function (DGF), the creatinine clearance (CrCL) on 10th day, and duration of hospital stay from the first posttransplant day till normalization of renal function was recorded and compared in two groups. Mean CrCL in posttransplant day 10, NTAD after 24 hours of transplantation, and urine output during 6 hours after operation were significantly better in Group I compared with Group II (𝑃<.05). Also, DGF during the first week after operation and duration of hospital stay was less in Group I compared with Group II. Intermittent exposure of human living kidney donor to hyperoxic environment may improve renal function following kidney transplantation. |
| format | Article |
| id | doaj-art-fd9405eb90e144719c9dcfba5a88ffa0 |
| institution | Kabale University |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-fd9405eb90e144719c9dcfba5a88ffa02025-02-03T01:01:58ZengWileyJournal of Transplantation2090-00072090-00152011-01-01201110.1155/2011/204843204843Short-Time Intermittent Preexposure of Living Human Donors to Hyperoxia Improves Renal Function in Early Posttransplant Period: A Double-Blind Randomized Clinical TrialKamran Montazeri0Mohammadali Vakily1Azim Honarmand2Parviz Kashefi3Mohammadreza Safavi4Shahram Taheri5Bahram Rasoulian6Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, P.O. Box 8174675731, Isfahan 81744, IranAnesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, P.O. Box 8174675731, Isfahan 81744, IranAnesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, P.O. Box 8174675731, Isfahan 81744, IranAnesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, P.O. Box 8174675731, Isfahan 81744, IranAnesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, P.O. Box 8174675731, Isfahan 81744, IranIsfahan Kidney Diseases Research Center (IKRC) and Internal Medicine Department, Alzahra Hospital, Isfahan University of Medical Sciences, P.O. Box 8174675731, Isfahan 81744, IranResearch Center and Department of Physiology, Lorestan University of Medical Sciences, P.O. Box 6814617767, Khorramabad, IranThe purpose of this human study was to investigate the effect of oxygen pretreatment in living kidney donors on early renal function of transplanted kidney. Sixty living kidney donor individuals were assigned to receive either 8–10 L/min oxygen (Group I) by a non-rebreather mask with reservoir bag intermittently for one hour at four times (20, 16, 12, and 1 hours before transplantation) or air (Group II). After kidney transplantation, urine output, blood urea nitrogen (BUN), serum creatinine, need to additional diuretics (NTADs) in the first 24 hours after transplantation, delayed graft function (DGF), the creatinine clearance (CrCL) on 10th day, and duration of hospital stay from the first posttransplant day till normalization of renal function was recorded and compared in two groups. Mean CrCL in posttransplant day 10, NTAD after 24 hours of transplantation, and urine output during 6 hours after operation were significantly better in Group I compared with Group II (𝑃<.05). Also, DGF during the first week after operation and duration of hospital stay was less in Group I compared with Group II. Intermittent exposure of human living kidney donor to hyperoxic environment may improve renal function following kidney transplantation.http://dx.doi.org/10.1155/2011/204843 |
| spellingShingle | Kamran Montazeri Mohammadali Vakily Azim Honarmand Parviz Kashefi Mohammadreza Safavi Shahram Taheri Bahram Rasoulian Short-Time Intermittent Preexposure of Living Human Donors to Hyperoxia Improves Renal Function in Early Posttransplant Period: A Double-Blind Randomized Clinical Trial Journal of Transplantation |
| title | Short-Time Intermittent Preexposure of Living Human Donors to Hyperoxia Improves Renal Function in Early Posttransplant Period: A Double-Blind Randomized Clinical Trial |
| title_full | Short-Time Intermittent Preexposure of Living Human Donors to Hyperoxia Improves Renal Function in Early Posttransplant Period: A Double-Blind Randomized Clinical Trial |
| title_fullStr | Short-Time Intermittent Preexposure of Living Human Donors to Hyperoxia Improves Renal Function in Early Posttransplant Period: A Double-Blind Randomized Clinical Trial |
| title_full_unstemmed | Short-Time Intermittent Preexposure of Living Human Donors to Hyperoxia Improves Renal Function in Early Posttransplant Period: A Double-Blind Randomized Clinical Trial |
| title_short | Short-Time Intermittent Preexposure of Living Human Donors to Hyperoxia Improves Renal Function in Early Posttransplant Period: A Double-Blind Randomized Clinical Trial |
| title_sort | short time intermittent preexposure of living human donors to hyperoxia improves renal function in early posttransplant period a double blind randomized clinical trial |
| url | http://dx.doi.org/10.1155/2011/204843 |
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