L-arginine dependence of breast cancer – molecular subtypes matter.

L-arginine dependence of breast cancer – molecular subtypes matter.

Abstract L-arginine limits proliferation in highly proliferative tissues. It is a substrate for nitric oxide synthases, arginases; its methylation by protein-L-arginine methyltransferases (PRMTs) leads to asymmetric (ADMA) and symmetric dimethylarginine (SDMA). We measured L-arginine and its metabol...

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Bibliographic Details
Main Authors: Juliane Hannemann, Leticia Oliveira-Ferrer, Anne Kathrin Goele, Yoana Mileva, Fiona Kleinsang, Antonia Röglin, Isabell Witzel, Volkmar Müller, Rainer Böger
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Cancer
Subjects:
Breast cancer subtypes
Biomarkers
Cancer metabolism
Breast cancer cell lines
Arginase
Translational research
Online Access:https://doi.org/10.1186/s12885-025-13908-4
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