The role and regulatory mechanism of lysosome associated protein transmembrane 4β in tumors

The oncogene LAPTM4B (encoding lysosome-associated protein transmembrane-4β), first cloned in hepatocellular carcinoma cells, is located on chromosome 8q22.1 and encodes two isoforms, LAPTM4B-35 and LAPTM4B-24. LAPTM4B proteins have four transmembrane structural domains and are mainly distributed in...

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Main Authors: Yuteng Yang, Yumei Li, Yaqi Wang, Xi Chen, Yisong Yao, Dongxian Li, Guohua Yu, Xicheng Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Oncology
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Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1552007/full
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