Machine learning-based proteomics profiling of ALS identifies downregulation of RPS29 that maintains protein homeostasis and STMN2 level

Machine learning-based proteomics profiling of ALS identifies downregulation of RPS29 that maintains protein homeostasis and STMN2 level

Abstract Amyotrophic lateral sclerosis (ALS) is a devastating motor neuron disease. The molecular understanding of ALS is hampered by the lack of experimental models recapitulating disease heterogeneity and analytical framework integrating multi-omics datasets. Here, we developed a pipeline integrat...

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Main Authors: Wei Xu, Zhipeng Guo, Yian Guan, Shihui Lv, Xue Gao, Wenchen Luo, Tianlin Cheng, Zhicheng Shao, Bangbao Tao, Tao Wang, Zhixin Qiu
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08578-8
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https://doi.org/10.1038/s42003-025-08578-8

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