Diabetic Retinopathy Is a Predictor of Progression of Diabetic Kidney Disease: A Systematic Review and Meta-Analysis
Aims and Objectives. This systematic review and meta-analysis aimed to assess the predictive value of diabetic retinopathy (DR) for progression of diabetic kidney disease (DKD). Methods. A systematic search was conducted on PubMed, Embase, and the Google scholar for eligible studies through Septembe...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2022/3922398 |
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| author | Mansi Gupta Indu Ramachandra Rao Shankar Prasad Nagaraju Sulatha V. Bhandary Jayanti Gupta Ganesh T. C. Babu |
| author_facet | Mansi Gupta Indu Ramachandra Rao Shankar Prasad Nagaraju Sulatha V. Bhandary Jayanti Gupta Ganesh T. C. Babu |
| author_sort | Mansi Gupta |
| collection | DOAJ |
| description | Aims and Objectives. This systematic review and meta-analysis aimed to assess the predictive value of diabetic retinopathy (DR) for progression of diabetic kidney disease (DKD). Methods. A systematic search was conducted on PubMed, Embase, and the Google scholar for eligible studies through September 2021. The quality of selected articles was assessed using JBI checklist. Higgins and Thompson’s I2 statistic was used to see the degree of heterogeneity. Based on degree of heterogeneity, fixed or random effects model was used to estimate pooled effect using inverse variance method. Results were expressed as hazard ratios and odds ratios with 95% CIs. Results. After scrutinizing 18017 articles, data from ten relevant studies (seven prospective and three retrospective) was extracted. DR was significantly associated with DKD progression with a pooled HR of 2.42 (95% CI: 1.70–3.45) and a pooled OR of 2.62 (95% CI: 1.76–3.89). There was also a significant association between the severity of DR and risk of progression of DKD with a pooled OR of 2.13 (95% CI: 1.82–2.50) for nonproliferative DR and 2.56 (95% CI: 2.93–.33) for proliferative DR. Conclusion. Our study suggests that presence of DR is a strong predictor of risk of kidney disease progression in DKD patients. Furthermore, the risk of DKD progression increases with DR severity. Screening for retinal vascular changes could potentially help in prognostication and risk-stratification of patients with DKD. |
| format | Article |
| id | doaj-art-fd0673a5068e4aef8f70f36c675dd2ca |
| institution | Kabale University |
| issn | 2090-2158 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-fd0673a5068e4aef8f70f36c675dd2ca2025-02-03T01:22:56ZengWileyInternational Journal of Nephrology2090-21582022-01-01202210.1155/2022/3922398Diabetic Retinopathy Is a Predictor of Progression of Diabetic Kidney Disease: A Systematic Review and Meta-AnalysisMansi Gupta0Indu Ramachandra Rao1Shankar Prasad Nagaraju2Sulatha V. Bhandary3Jayanti Gupta4Ganesh T. C. Babu5Center of Application and Research in IndiaDepartment of NephrologyDepartment of NephrologyDepartment of OphthalmologyNishkash ConsultingCenter of Application and Research in IndiaAims and Objectives. This systematic review and meta-analysis aimed to assess the predictive value of diabetic retinopathy (DR) for progression of diabetic kidney disease (DKD). Methods. A systematic search was conducted on PubMed, Embase, and the Google scholar for eligible studies through September 2021. The quality of selected articles was assessed using JBI checklist. Higgins and Thompson’s I2 statistic was used to see the degree of heterogeneity. Based on degree of heterogeneity, fixed or random effects model was used to estimate pooled effect using inverse variance method. Results were expressed as hazard ratios and odds ratios with 95% CIs. Results. After scrutinizing 18017 articles, data from ten relevant studies (seven prospective and three retrospective) was extracted. DR was significantly associated with DKD progression with a pooled HR of 2.42 (95% CI: 1.70–3.45) and a pooled OR of 2.62 (95% CI: 1.76–3.89). There was also a significant association between the severity of DR and risk of progression of DKD with a pooled OR of 2.13 (95% CI: 1.82–2.50) for nonproliferative DR and 2.56 (95% CI: 2.93–.33) for proliferative DR. Conclusion. Our study suggests that presence of DR is a strong predictor of risk of kidney disease progression in DKD patients. Furthermore, the risk of DKD progression increases with DR severity. Screening for retinal vascular changes could potentially help in prognostication and risk-stratification of patients with DKD.http://dx.doi.org/10.1155/2022/3922398 |
| spellingShingle | Mansi Gupta Indu Ramachandra Rao Shankar Prasad Nagaraju Sulatha V. Bhandary Jayanti Gupta Ganesh T. C. Babu Diabetic Retinopathy Is a Predictor of Progression of Diabetic Kidney Disease: A Systematic Review and Meta-Analysis International Journal of Nephrology |
| title | Diabetic Retinopathy Is a Predictor of Progression of Diabetic Kidney Disease: A Systematic Review and Meta-Analysis |
| title_full | Diabetic Retinopathy Is a Predictor of Progression of Diabetic Kidney Disease: A Systematic Review and Meta-Analysis |
| title_fullStr | Diabetic Retinopathy Is a Predictor of Progression of Diabetic Kidney Disease: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Diabetic Retinopathy Is a Predictor of Progression of Diabetic Kidney Disease: A Systematic Review and Meta-Analysis |
| title_short | Diabetic Retinopathy Is a Predictor of Progression of Diabetic Kidney Disease: A Systematic Review and Meta-Analysis |
| title_sort | diabetic retinopathy is a predictor of progression of diabetic kidney disease a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2022/3922398 |
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