Mathematical rules for synergistic, additive, and antagonistic effects of multi-drug combinations and their application in research and development of combinatorial drugs and special medical food combinations
Multi-drug (or multi-element) combinations are often prescribed in the practice of clinical medicine and as foods for special medical purposes. The main motivations for these combinations are that most diseases contain multiple related targets and an appropriate combination can maximize benefits whi...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2019-06-01
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| Series: | Food Science and Human Wellness |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453019300321 |
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| author | Shoujun Yuan Haoyu Chen |
| author_facet | Shoujun Yuan Haoyu Chen |
| author_sort | Shoujun Yuan |
| collection | DOAJ |
| description | Multi-drug (or multi-element) combinations are often prescribed in the practice of clinical medicine and as foods for special medical purposes. The main motivations for these combinations are that most diseases contain multiple related targets and an appropriate combination can maximize benefits while minimizing adverse reactions. As such, it is especially important to derive mathematical models for their quantitative calculation. In this paper, we introduce mathematical rules for the synergistic, additive, and antagonistic effects of multi-drug combinations developed in our laboratory. We have established a “one-belt, one-line” model and provide examples of the quantitative calculation of the synergistic, additive, and antagonistic effects of a combination of multiple components. We also explain how to scientifically and precisely determine the intensity of these synergies, additions and antagonisms, as well as their corresponding dose ranges, thereby laying a solid theoretical foundation for market listing combinatorial drugs and foods for special medical purposes. Keywords: Multi-drug combination, Dose–effect belt, One-belt, one-line model, Foods for special medical purposes, Synergy, Addition, Antagonism |
| format | Article |
| id | doaj-art-fcf2d837da96405aa7c138e48a6cde07 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2019-06-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-fcf2d837da96405aa7c138e48a6cde072025-02-03T02:38:43ZengTsinghua University PressFood Science and Human Wellness2213-45302019-06-0182136141Mathematical rules for synergistic, additive, and antagonistic effects of multi-drug combinations and their application in research and development of combinatorial drugs and special medical food combinationsShoujun Yuan0Haoyu Chen1Beijing Institute of Radiation Medicine, Academy of Military Medical Sciences (AMMS), Beijing 100850, China; Beijing Brightshines Technology Co. Ltd., China; Corresponding author at: Beijing Institute of Radiation Medicine, Academy of Military Medical Sciences (AMMS), Beijing 100850, China.Beijing Brightshines Technology Co. Ltd., ChinaMulti-drug (or multi-element) combinations are often prescribed in the practice of clinical medicine and as foods for special medical purposes. The main motivations for these combinations are that most diseases contain multiple related targets and an appropriate combination can maximize benefits while minimizing adverse reactions. As such, it is especially important to derive mathematical models for their quantitative calculation. In this paper, we introduce mathematical rules for the synergistic, additive, and antagonistic effects of multi-drug combinations developed in our laboratory. We have established a “one-belt, one-line” model and provide examples of the quantitative calculation of the synergistic, additive, and antagonistic effects of a combination of multiple components. We also explain how to scientifically and precisely determine the intensity of these synergies, additions and antagonisms, as well as their corresponding dose ranges, thereby laying a solid theoretical foundation for market listing combinatorial drugs and foods for special medical purposes. Keywords: Multi-drug combination, Dose–effect belt, One-belt, one-line model, Foods for special medical purposes, Synergy, Addition, Antagonismhttp://www.sciencedirect.com/science/article/pii/S2213453019300321 |
| spellingShingle | Shoujun Yuan Haoyu Chen Mathematical rules for synergistic, additive, and antagonistic effects of multi-drug combinations and their application in research and development of combinatorial drugs and special medical food combinations Food Science and Human Wellness |
| title | Mathematical rules for synergistic, additive, and antagonistic effects of multi-drug combinations and their application in research and development of combinatorial drugs and special medical food combinations |
| title_full | Mathematical rules for synergistic, additive, and antagonistic effects of multi-drug combinations and their application in research and development of combinatorial drugs and special medical food combinations |
| title_fullStr | Mathematical rules for synergistic, additive, and antagonistic effects of multi-drug combinations and their application in research and development of combinatorial drugs and special medical food combinations |
| title_full_unstemmed | Mathematical rules for synergistic, additive, and antagonistic effects of multi-drug combinations and their application in research and development of combinatorial drugs and special medical food combinations |
| title_short | Mathematical rules for synergistic, additive, and antagonistic effects of multi-drug combinations and their application in research and development of combinatorial drugs and special medical food combinations |
| title_sort | mathematical rules for synergistic additive and antagonistic effects of multi drug combinations and their application in research and development of combinatorial drugs and special medical food combinations |
| url | http://www.sciencedirect.com/science/article/pii/S2213453019300321 |
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