Nonsteroidal Anti-Inflammatory Drugs and Risk of Melanoma
Because nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit tumor growth in vitro, we investigated the association between NSAIDs and melanoma to determine if there was epidemiologic evidence of a chemopreventive effect from these medications. Three hundred twenty-seven subjects with incident mela...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Skin Cancer |
| Online Access: | http://dx.doi.org/10.1155/2011/598571 |
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| _version_ | 1832564582773686272 |
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| author | Joanne M. Jeter Joseph D. Bonner Timothy M. Johnson Stephen B. Gruber |
| author_facet | Joanne M. Jeter Joseph D. Bonner Timothy M. Johnson Stephen B. Gruber |
| author_sort | Joanne M. Jeter |
| collection | DOAJ |
| description | Because nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit tumor growth in vitro, we investigated the association between NSAIDs and melanoma to determine if there was epidemiologic evidence of a chemopreventive effect from these medications. Three hundred twenty-seven subjects with incident melanoma and 119 melanoma-free controls completed a structured interview assessing melanoma risk factors. The unadjusted odds ratio (OR) for use of nonaspirin NSAIDs was 0.58 (95% CI 0.31–1.11), in a comparison of subjects with melanoma to controls. After adjustment for melanoma risk factors, the OR was 0.71 (95% CI 0.23–2.02). Aspirin users had an unadjusted OR of 0.85 (95% CI 0.45–1.69) and an adjusted OR of 1.45 (95% CI 0.44–4.74). In this pilot study, we found no evidence of a significant association between analgesic use and melanoma risk when potential confounders are assessed. Based on conflicting reports in the literature, meta-analysis may be appropriate. |
| format | Article |
| id | doaj-art-fcd7c1488ffe42b59a6b34e06d5e7f56 |
| institution | Kabale University |
| issn | 2090-2905 2090-2913 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Skin Cancer |
| spelling | doaj-art-fcd7c1488ffe42b59a6b34e06d5e7f562025-02-03T01:10:43ZengWileyJournal of Skin Cancer2090-29052090-29132011-01-01201110.1155/2011/598571598571Nonsteroidal Anti-Inflammatory Drugs and Risk of MelanomaJoanne M. Jeter0Joseph D. Bonner1Timothy M. Johnson2Stephen B. Gruber3University of Michigan Cancer Center, 1500 East Medical Center, Ann Arbor, MI 48109, USAUniversity of Michigan Cancer Center, 1500 East Medical Center, Ann Arbor, MI 48109, USAUniversity of Michigan Cancer Center, 1500 East Medical Center, Ann Arbor, MI 48109, USAUniversity of Michigan Cancer Center, 1500 East Medical Center, Ann Arbor, MI 48109, USABecause nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit tumor growth in vitro, we investigated the association between NSAIDs and melanoma to determine if there was epidemiologic evidence of a chemopreventive effect from these medications. Three hundred twenty-seven subjects with incident melanoma and 119 melanoma-free controls completed a structured interview assessing melanoma risk factors. The unadjusted odds ratio (OR) for use of nonaspirin NSAIDs was 0.58 (95% CI 0.31–1.11), in a comparison of subjects with melanoma to controls. After adjustment for melanoma risk factors, the OR was 0.71 (95% CI 0.23–2.02). Aspirin users had an unadjusted OR of 0.85 (95% CI 0.45–1.69) and an adjusted OR of 1.45 (95% CI 0.44–4.74). In this pilot study, we found no evidence of a significant association between analgesic use and melanoma risk when potential confounders are assessed. Based on conflicting reports in the literature, meta-analysis may be appropriate.http://dx.doi.org/10.1155/2011/598571 |
| spellingShingle | Joanne M. Jeter Joseph D. Bonner Timothy M. Johnson Stephen B. Gruber Nonsteroidal Anti-Inflammatory Drugs and Risk of Melanoma Journal of Skin Cancer |
| title | Nonsteroidal Anti-Inflammatory Drugs and Risk of Melanoma |
| title_full | Nonsteroidal Anti-Inflammatory Drugs and Risk of Melanoma |
| title_fullStr | Nonsteroidal Anti-Inflammatory Drugs and Risk of Melanoma |
| title_full_unstemmed | Nonsteroidal Anti-Inflammatory Drugs and Risk of Melanoma |
| title_short | Nonsteroidal Anti-Inflammatory Drugs and Risk of Melanoma |
| title_sort | nonsteroidal anti inflammatory drugs and risk of melanoma |
| url | http://dx.doi.org/10.1155/2011/598571 |
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