Integrated multi-omics of feces, plasma and urine can describe and differentiate pediatric active Crohn’s Disease from remission

Integrated multi-omics of feces, plasma and urine can describe and differentiate pediatric active Crohn’s Disease from remission

Abstract Background This study aimed to obtain a holistic view of remission in pediatric Crohn’s Disease (CD) by integrating six omics datasets from three anatomical compartments. Methods Patients with fecal calprotectin below 250 mg/kg were considered in remission (n = 27), above 250 mg/kg as havin...

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Main Authors: Nienke Koopman, Yorrick Jaspers, Pim T. van Leeuwen, Konstantinos Chronas, Andrew Y. F. Li Yim, Kay Diederen, Anje A. te Velde, Winfried Roseboom, Angelika Kindermann, Marc A. Benninga, Gertjan Kramer, Wouter J. de Jonge, Stanley Brul, Evgeni Levin, Stephan Kemp, Jurgen Seppen
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-025-00984-7
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https://doi.org/10.1038/s43856-025-00984-7

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