Zuoqing granules attenuate ulcerative colitis via macrophage polarization modulation: involvement of the PPAR-γ/NF-κB/STAT1 signaling axis

Zuoqing granules attenuate ulcerative colitis via macrophage polarization modulation: involvement of the PPAR-γ/NF-κB/STAT1 signaling axis

BackgroundAlthough our prior clinical study demonstrated the efficacy of Zuoqing granules (ZQGs) in treating ulcerative colitis (UC), the underlying immunomodulatory mechanisms remained unclear. This study systematically investigated ZQG’s therapeutic effects through macrophage polarization modulati...

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Bibliographic Details
Main Authors: Heng Deng, Ming Li, Xiaoli Fang, Kun Tang, Shuqing Xu, Rui Ding, Zilong Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
Zuoqing granules
ulcerative colitis
macrophage polarization
PPAR-γ/NF-κB/STAT1 signaling
traditional Chinese medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1646545/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1646545/full

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