The Immunohistochemistry Profile of Lymphocytic Gastritis in Celiac Disease and Helicobacter Pylori Infection: Interplay between Infection and Inflammation
Lymphocytic gastritis (LG) is associated with helicobacter pylori (Hp) and celiac disease (CD). We aimed to clarify the relationship between Hp infection and CD by defining a unique histopathology profile of LG in these two diseases. Forty patients who underwent upper endoscopy wer...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2007-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2007/81838 |
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| Summary: | Lymphocytic gastritis (LG) is associated with helicobacter pylori (Hp) and celiac
disease (CD). We aimed to clarify
the relationship between Hp infection and CD by defining a unique histopathology profile of
LG in these two diseases.
Forty patients who underwent upper endoscopy were divided into four groups: eight controls, ten active
CD patients
without Hp, twelve CD negative with Hp, and ten active CD with Hp infection. Antral samples were assessed by
immunohistochemical staining for CD20, CD3, CD4, CD8, CD57, CNA42, and Ki67 for lymphoid aggregates,
intraepithelial lymphocytes (IELs) number, density of lamina propria (LP) lymphocytes, and inflammatory
glandular
involvement. Only IELs positive for CD3 and CD8 were increased significantly in CD patients with or without
Hp infection.
Hp did not contribute to the number of CD8 IELs. In complicated cases with Hp and suspicious
for CD, the number of
CD8+ IELs hints toward a CD rather than Hp infection. |
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| ISSN: | 0962-9351 1466-1861 |