Interactions between glucocorticoid treatment and cis-regulatory polymorphisms contribute to cellular response phenotypes.

Glucocorticoids (GCs) mediate physiological responses to environmental stress and are commonly used as pharmaceuticals. GCs act primarily through the GC receptor (GR, a transcription factor). Despite their clear biomedical importance, little is known about the genetic architecture of variation in GC...

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Bibliographic Details
Main Authors: Joseph C Maranville, Francesca Luca, Allison L Richards, Xiaoquan Wen, David B Witonsky, Shaneen Baxter, Matthew Stephens, Anna Di Rienzo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-07-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002162&type=printable
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