Different Mitotic Arrest Targets of Chemoprevention Curcumin Analog 1.1 (CCA-1.1) and Pentagamavunone-1 (PGV-1) in Leukemic K-562 Cells

Different Mitotic Arrest Targets of Chemoprevention Curcumin Analog 1.1 (CCA-1.1) and Pentagamavunone-1 (PGV-1) in Leukemic K-562 Cells

Background: Pentagamavunone-1 (PGV-1) is a promising cytotoxic chemotherapy agent in many cancer cells. However, due to its structure, PGV-1 is unstable and easily decomposed by light or high pH, causing decreased cytotoxic effect. Therefore, we developed a chemoprevention curcumin analog (CCA-1.1),...

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Main Authors: Riris Istighfari Jenie, Dhania Novitasari, Dyaningtyas Dewi Pamungkas Putri, Ratna Asmah Susidarti, Ikuko Nakamae, Noriko Yoneda-Kato, Jun-ya Kato, Edy Meiyanto
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2025-01-01
Series:Pharmaceutical Sciences
Subjects:
antimitotic agents
cellular senescence
chronic myeloid leukemia
curcumin analogs
m phase cell cycle arrest
mitotic index
Online Access:https://ps.tbzmed.ac.ir/PDF/ps-31-96.pdf
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https://ps.tbzmed.ac.ir/PDF/ps-31-96.pdf

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