Diarrheal microbiota-derived extracellular vesicles drive intestinal homeostasis dysfunction via miR-125b/NF-κB-mediated macrophage polarization

Diarrheal microbiota-derived extracellular vesicles drive intestinal homeostasis dysfunction via miR-125b/NF-κB-mediated macrophage polarization

Gut microbiota-derived extracellular vesicles (EVs) are emerging mediators of microbiota-host crosstalk, but their roles in diarrheal diseases remain poorly understood. Here, we revealed that EVs isolated from diarrheal donors’ intestinal microbiota trigger pro-inflammatory macrophage polarization a...

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Bibliographic Details
Main Authors: Mengzhen Song, Wenjun Zhou, Jinping Fan, Chenhao Jia, Wen Xiong, Hong Wei, Shiyu Tao
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gut Microbes
Subjects:
Extracellular vesicles
miR-125b
macrophage polarization
intestinal inflammatory injury
diarrhea
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2025.2541036
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https://www.tandfonline.com/doi/10.1080/19490976.2025.2541036

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